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To date, five families of Keap1-Nrf2 PPI inhibitors have been described: tetrahydroisoquinoline, thiopyrimidine, naphthalene, carbazone, and urea derivatives (reviewed recently in Cuadrado et al., 2018) and studies show that these peptides are excellent candidates to activate Nrf2 due to their potent activity and specificity (Hancock et al., 2012, 2013)
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