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These results allowed the designation of metformin as an orphan drug for the treatment of Lafora disease by the European Medicines Agency (EMA) in 2016 and the United States Food and Drug Administration (FDA) in 2017
B12 Deficiency Treatment
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Lastly, it is essential to mention a clinical trial that investigated the influence of the genetic variability of alcohol metabolizing enzymes in 101 AUD patients treated with naltrexone
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