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Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation | Journal of Hematology & Oncology | Springer Nature Link

A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 allele” “However, the precise dose reduction in this patient population is not known” Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Other polymorphisms of UGT due to random genetic differences have been reported, but only a few have suggested to influence drug metabolism in the clinic

2026-08-10

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Discussion Here we report on the development of the NAPstar family of genetically encoded fluorescent probes for in cell monitoring of the NADP redox state

8 and 22ml respectively