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An animal study showed that rats on a ketogenic diet during metabolic adaptation (approximately 3 weeks) exhibited increased production of H 2 O 2 originating from the hippocampus mitochondria and 4-hydroxynonenal (4-HNE), a product of lipid peroxidation
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Metabolic Health & Insulin Sensitivity Modulation of NNMT activity has been associated with improved glucose handling and insulin sensitivity, suggesting potential benefits in metabolic syndrome and related conditions²⁻⁴
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