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Statistical Analysis The statistical analyses were conducted using parametric one-way ANOVAs with post hoc Newman–Keuls tests, non-parametric Kruskal–Wallis tests, and subsequent Mann–Whitney U tests to compare groups
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This finding shows that all three domains of SOCS2 (N-terminal ESS, SH2, and SOCS box) can undergo conformational changes and work together to channel their substrates to ubiquitin-mediated degradation
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