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In hypertensive vessels, eNOS S-glutathionylation was enhanced with impaired endothelium-dependent vasodilation rescued by thiol-specific reducing agents, which reversed the S-glutathionylation
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Retro-inverso mimicry has therefore been observed to work best for interactions dominated by side-chain contacts in extended conformations, and to be less faithful where an α-helical backbone geometry carries much of the binding energy (Chorev and Goodman, Accounts of Chemical Research , 1993
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