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Natural polyphenols rich in catechol groups can form dynamic complex structures with metal ions, and complex dissociation occurs under acidic conditions and the influence of protonation, which achieves both structural response and drug release [70]

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Consequently, in patients with PCOS, this can worsen hyperandrogenism by increasing the synthesis of androgen precursors in the ovaries and adrenal glands due to increased CYP17A1 activity (Pusalkar et al., 2009)