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To solve these issues, they redesigned liquid-injecting SOMA (L-SOMA), enabling a higher drug-loading capacity (~4 mg) for liquid drugs like recombinant human insulin, GLP-1 analogs, adalimumab, and epinephrine directly into the gastric submucosa using dissolvable isomalt pellets to activate a needle- and plunger-based mechanism (Figure 5C)
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size:10Mg
However, this would require a change to their January 7, 2025 guidelines that essentially ended Category 1 for bulk drug substances nominated on or after January 7, 2025
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