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Trigger point injections may be worth discussing when: You have one or more tender muscle knots causing ongoing pain The pain hasn’t settled with stretching, therapy, or medication Your physician can feel a distinct trigger point on exam You want a targeted step alongside physical therapy and activity changes According to NIH’s StatPearls reference, trigger point injections can be an effective primary or add-on therapy for musculoskeletal pain — but they aren’t right for everyone, and your physician will confirm whether they fit your situation