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Statistical analysis was performed using two-tailed one-way ANOVA test followed by unpaired t-tests of means indicated by P-values (d-f, h-j)
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Moreover, unlike with nutlin-3 (Fig 1C) (Tarangelo et al, 2018), MPA and Pyr pretreatment protected both p53 KO and p21 KO cells from erastin2-induced cell death, consistent with RNR acting downstream of the p53/p21 axis
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