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Structural superposition of the palm subdomain of hepatitis C virus (HCV) RNA polymerase (PDB: 1NB6) to that of MARL suggests that the 744 GDN 746 motif together with the residue D635 from motif A may play a role in coordinating two magnesium ions, which are required for catalyzing the formation of phosphodiester bonds through a potential “two-metal-catalysis” mechanism (Fig