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134 The NLRP3 is also upregulated resulting from activated NF-κB, and activates caspase 1 which induces β cell pyroptosis, a type of programmed cell death characterized by the formation of pores in the plasma membrane, leading to the release of proinflammatory cytokines and subsequent cell lysis 38,135 (Fig

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Rather, they form an interconnected regulatory network in which multiple transcription factors converge on shared promoter elements, cross-regulate each other, and exhibit cell-type- and context-dependent interactions