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The hazard ratio for progression free survival was 0.44 (95% CI, 0.39 to 0.51) stratified on prognostic category, and the hazard ratio for overall survival was 0.65 (95% CI, 0.56 to 0.75), favoring high-dose chemotherapy: High-dose chemotherapy was also beneficial compared to conventional dose chemotherapy with regards to progression free survival across all risk groups: There are several high-dose chemotherapy regimens available, including carboplatin etoposide regimen x 2: Another regimen used for high-dose chemotherapy is the TI-CE regimen: Both Indiana University and Memorial Sloan Kettering Cancer Center (MSKCC) have published their series’ of salvage high-dose chemotherapy, Indiana using the carboplatin + etoposide regimen and MSKCC using the TI-CE regimen, with comparable results: In 2017, Dr

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Advances in display technologies, structural epitope profiling, and biophysical optimization can facilitate the discovery of antibodies targeting functionally relevant epitopes