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Based on measured in vitro pharmacokinetics values (Cl int in rat primary hepatocyte cultures), the in vivo hepatic clearance (Cl H ) in rat was predicted to be 10.1, 28.4 and 29.6 ml/min/kg for JNK-IN-8, 1a R -IN-8, and PK_test, respectively (Supplementary Table 4) 44
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